Asian Fisheries Society

Neuroendocrine Regulation of Growth Hormone Secretion and Body Growth in Carp: A Review


Growth hormone (GH) secretion in carp is stimulated by a number of neuropeptides (e.g. GH-releasing factor, gonadotropin-releasing hormone, thyrotropin-releasing hormone, etc.) and neurotransmitters (e.g., dopamine). Sex steroids potentiate the responsiveness of the somatotrophs to neuroendocrine factors. Somatostatin is the primary inhibitory control of basal and stimulated GH release. Norepinephrine and serotonin also inhibit GH release. Carp GH, a 188-amino acid peptide with five systeine residues, controls the rate of body growth. Treatment with a superactive agonist analog of luteinizing hormone releasing hormone (LHRH) by intraperitoneal injection, esophageal intubation or feeding is effective in stimulating GH release and body growth of grass carp Ctenopharyngodon idella. Injection or feeding with dopamine receptor agonists (e.g. apomorphine) also stimulates GH release and body growth of grass carp. Treatment with recombinant fish GH by injection or feeding signigicantly increased serum GH levels and growth rate of grass carp. Treatment with LHRH-A, dopamine D-1 receptor agonists or exogenous recombinant GH by feeding constitutes a practical approach to accelerate the growth of cultured carp.

Publication Date : 1997-09-01

Volume : 10

Issue : 1

Page : 23-28

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Date 1997/09/01
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